Feedback Control and State Estimation of an Hiv Model
نویسنده
چکیده
We consider optimal dynamic multidrug therapies for human immunodeficiency virus(HIV) type 1 infection. We describe an optimal tracking problem attempting to move the state of the system from an “unhealthy” state (high virus load and low immune response) to a “healthy” one (with low viral load and high immune effector levels). We consider feedback control with full state as well as with partial state measurements. In the case of partial state measurement, a state estimator is constructed based on viral load and T-cell count measurements. In addition, the state estimation based on a moving horizon type approach is introduced.
منابع مشابه
Sub-optimal Estimation of HIV Time-delay Model using State-Dependent Impulsive Observer with Time-varying Impulse Interval: Application to Continuous-time and Impulsive Inputs
Human Immunodeficiency Virus (HIV) weakens the immune system in confronting various diseases by attacking to CD4+T cells. In modeling HIV behavior, the number of CD4+T cells is considered as the output. But, continuous-time measurement of these cells is not possible in practice, and the measurement is only available at variable intervals that are several times bigger than sampling time. In this...
متن کاملPDC Control of Time Delay Fuzzy T-S modeled HIV-1 System through Drug Dosage
This paper proposes a Time Delay nonlinear dynamic model of HIV-1 (Human Immunodeficiency Virus type 1), introducing the drug consumption efficiencies as the controlling input for the model. The paper also represents the fuzzy T-S representation and the corresponding Fuzzy T-S controller. The controller parameters are tuned using LMIs (Linear Matrix Inequalities). The main focus is on the stabi...
متن کاملA Novel Qualitative State Observer
The state estimation of a quantized system (Q.S.) is a challenging problem for designing feedback control and model-based fault diagnosis algorithms. The core of a Q.S. is a continuous variable system whose inputs and outputs are represented by their corresponding quantized values. This paper concerns with state estimation of a Q.S. by a qualitative observer. The presented observer in this pape...
متن کاملSaturated Neural Adaptive Robust Output Feedback Control of Robot Manipulators:An Experimental Comparative Study
In this study, an observer-based tracking controller is proposed and evaluatedexperimentally to solve the trajectory tracking problem of robotic manipulators with the torque saturationin the presence of model uncertainties and external disturbances. In comparison with the state-of-the-artobserver-based controllers in the literature, this paper introduces a saturated observer-based controllerbas...
متن کاملComparative study of predictive ability of AIDS incidence in HIV positive people using Markov model according to two criteria, WHO and CDC in CD4 cell categorization
Background: The Multi state Markov models have extensively application with categorization of laboratory marker of CD4 cells for evaluation of HIV disease progression. These models with different states result in different effects of covariates and prediction of HIV disease trend. The main purpose of this study was comparison of four and five states models with the three- state in order to sele...
متن کاملOptimal Integral State Feedback Control of HCCI Combustion Timing
Homogenous Charge Compression Ignition (HCCI) engines hold promise of high fuel efficiency and low emission levels for future green vehicles. But in contrast to gasoline and diesel engines, HCCI engines suffer from lack of having direct means to initiate combustion. A combustion timing controller with robust tracking performance is the key requirement to leverage HCCI application in production ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006